Pharma collo 2

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• Clavulanic acid is a an... beta-lactamase inhibitor​
• Simultaneous administration of cephalosporins and anticoagulants as Warfarin.... risk of bleeding
• medicines is a pro-drug ​(first inactive > metabolized > active) ribavirin
• Acyclovir can be used against... herpes virus
• ​Oseltamivir, ​Zanamivir can be used against... influensa virus
• Ribavirin can be used against.. hepatitis C virus
• Zanamivir used against influenca virus.. given in inhalation and is well tolerated
• Macrolides (Erythromycin, clarithromycin, azithromycin) against influenca virus.. is given intravenousy and causes arrhythmias
• Azole antifungal drug, By blocking fungal enzyme responsible for lanosterol into ergosterol transformation fluconazole
• inhibiting dna production in fast dividing dividing cells, cause fearst bleeding and diarrhea, blocking reproductive cell production, hand foot syndrome flucytozine
• Antifungal for topical and systemic use, high cumulative in the nails and keratin rich cells, which can be used once and be active for 30 days terbinafine
• Blocking of haem-polymerase is a mechanism of action of chloroquine (antimalaria drug)
• Plant derivative, used with lumefantrine Artemisine
• Psychiatric side effects can be observed especially during therapy with... mefloquine
• Folate antagonist, used together with Atovaquone, never used alone proguanil
• Treatment for leprosy, hemolysis of RBC in longer period of treatment dapsone
• Second generation III receptor antagonist vs. first generation III receptor antagonist produces less side effects
• A serotonin 5-HT3 receptor antagonist (e.g. granisetron), can be used as... antiemetic to treat nausea following chemotherapy
• Azithromycin is a macrolide, so it is... bacteriostatic
• Fluconazole is an ​enzymatic inhibitor ​, and ​rarely cause life threatening side effects true
• Mechanism of action of macrolides is... inhibition of protein synthesis
• Mechanism of action of B-lactams and Glycopeptides inhibition of cell wall creation
• Mechanism of action of Quiniloles Inhibitoon of DNA Polymerase
• Metabolism of isoniazid depends on activity of enzymes. There are two groups, slow and fast metabolizers, with different toxicity profiles. isoniazid is metabolized mainly by... acetylation ​(liver)
• Co-Trimoxazole (Sulfonamides) is acting as progunalil, by: inhibition of folate synthesis
• Side effects of fluoroquinolones prolonged QT interval and torsades de pointes ​(And macrolides, and many others), tendonitis, liver toxicity
• During pregnancy can be safely used.. amoxicillin
• By acting on topoisomerase-II ​ ciprofloxacin
• Antiprotozoal medication: ​Nucleic acid synthesis; Create free radicals metronidazole
• Ethambutol specific toxicity is.. Optic neuritis, cause red-green colorblindness
• Patient who show allergic reactions for β-lactams, should not be treated with cephalosporins
• Macrolides ● Streptogramines ● Clindamycin (Lincosamide) ● Linezolid ● Chloramphenicol Inhibit 50S subunit
• Tetracyclines ● Aminoglycosides ● Tigecycline Inhibit 30S subunit:
• abacavir ● maraviroc ● Didanosine ● Emtricitabine ● Lamivudine ● Stavudine ● Tenofovir For HIV
• Combined with metal-ions (vitamins, dairy products, micro-/macroelement pills) will have a diminished bioavailability: Fluoroquinolones ● Tetracyclines
• Antibiotics combined oral contraceptives (ex. P-pills), reduces the contraceptive pills: Rifampicin, Rifabutin

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