Effects on heart

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• Chronotropy affects heart rate, conduction cells
• Inotropy affects contractility, myocardial cells
• Bathmotropy affects excitation, conduction cells
• Dromotropy affects velocity through AV node, conduction cells
• Lusitropy affects relaxation, myocardial cells
• positive chronotropy If + L-type C2+
• negative chronotropy If + L-type Ca2+ + inhibit release of adrenaline
• Positive inotropy L-type Ca2+ + protein kinase A --> phosphorylation of phospholamban
• negative inotropy L-type Ca2+ + protein kinase A + increased K+ to shorter plateau
• positive bathmotrophy Trap Na+ inside
• positive dromotropy L-type ca2+
• negative dromotropy L-type Ca2+ + increased K+
• positive lusitropy L-type Ca2+ + protein kinase A --> phosphorylation of phospholamban + troponin I
• negative lusitropy same as positive

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